Sex as a Biological Covariate in QTL Studies

Goals of this webinar (trait variance to QTL):

  • Review QTL mapping

  • Understand the role of sex in QTL study design

  • Use sex as a covariate in QTL analysis

  • Understand X chromosome segregation in crosses

  • Make adjustments for X chromosome in QTL analysis

Presented by:

Dr. Saunak Sen
Professor and Chief of Biostatistics
Department of Preventative Medicine
University of Tennessee Health Science Center

Identifying genes from QTL using RNA expression and the PhenoGen website (http://phenogen.org)

Goals of this webinar (candidate genes to causal variants):

Demonstrate how to use the PhenoGen website to identify transcripts:

  • Physically located within a QTL

  • Physically located within a QTL and expressed in brain

  • With a brain cis eQTL within the QTL

  • With any brain eQTL within the QTL

  • Within a co-expression network controlled from the same region as the QTL

Presented by:

Dr. Laura Saba
Associate Professor
Department of Pharmaceutical Sciences
University of Colorado Anschutz Medical Campus

From Candidate Genes to Causal Variants—Strategies for and Examples of Identifying Genes and Sequence Variants in Rodent Populations

Goals of this webinar (candidate genes to causal variants):

  • To understand when it is practical or (just as often) not practical to try to "clone" the gene or nucleotide variant modulating trait variants

  • To understand that defining the crucial causal nucleotide variant is usually a bonus and often not for the translational or even mechanistic utility of discoveries.

  • To review new sequence-based methods to identify common and rare variants—the reduced complexity cross and epoch-effects in reference populations

Presented by:

Dr. Rob Williams
Professor and Chair
Department of Genetics, Genomics, and Informatics
University of Tennessee Health Science Center

Introduction to expression (e)QTL and their role in connecting QTL to genes and molecular networks

in

Goals of this webinar (QTL to gene/molecular networks):

  • Define eQTL

  • Examine the role of eQTL in the relationship of genes and molecular networks with phenotypic QTL

  • eQTL for co-expression networks

Presented by:

Dr. Laura Saba
Associate Professor
Department of Pharmaceutical Sciences
University of Colorado Anschutz Medical Campus

Introduction to Quantitative Trait Locus (QTL) Mapping

in

Presented By:

Saunak Sen
Professor and Chief of Biostatistics
Department of Preventive Medicine
University of Tennessee Health Science Center
sen@uthsc.edu ~ @saunaksen ~ http://www.senresearch.org

Goals of Webinar:

  • What is a quantitative trait locus (QTL)?

  • Why are we interested in them?

  • What are genome scans and how do they help find QTL?

  • What are the strengths and limitations of QTL mapping?